Craig Knox joined the Pittsburgh Symphony Orchestra as Principal Tuba in 2005. His previous orchestra positions included Acting Principal Tuba of the San Francisco Symphony as well as Principal Tuba of the Sacramento Symphony and the New World Symphony (Miami). Prior to his appointment in Pittsburgh, he was in demand as regular guest artist with many other major American orchestras, including those of Philadelphia, Cleveland, Chicago, Detroit and Minnesota. Since 1995, he has spent part of each summer as Co-Principal Tuba of the Grand Teton Music Festival in Jackson, Wyoming.

Since joining the PSO, Knox also performs with the Pittsburgh Symphony Brass. He has been an active chamber musician for many years, having co-founded the Center City Brass Quintet, which has performed in recital throughout the U.S. and Japan, and been heard numerous times on NPR. Its five recordings on the Chandos label have met with critical acclaim, the first being described by American Record Guide as "one of the all-time great brass quintet recordings." In addition, he played for several seasons with the Chicago Chamber Musicians Brass Quintet - with which he recorded for the Naxos label - and has toured with the Empire Brass.

In January 2012, Mr. Knox released his first solo recording, A Road Less Traveled, of music for tuba and piano. As a soloist, he has performed with the U.S. Army Band (Pershing's Own) in Washington D.C., the Tokyo Symphony Orchestra, the New World Symphony, and the Carnegie Mellon University Wind Ensemble, in addition to recital performances at universities and music festivals around the world. 

In 2008, the Albany label released a CD recording featuring Knox and his colleagues in the PSO low-brass section. Featuring chamber music, orchestral collections and original compositions for three trombones and tuba, the album - titled From the Back Row - was called "hauntingly beautiful" and "hair-raising" by the American Record Guide.

Knox is Artist Lecturer of Tuba at Carnegie Mellon University and Adjunct Professor of Tuba at Duquesne University. He previously served on the faculty at Kent State University, California State University-Hayward, as well as the San Francisco Conservatory of Music, where he was Director of the Brass Chamber Music program. He has presented master classes, seminars and recitals at universities, conservatories and festivals around the world, including the Music Masters Course in Kazusa, (Japan), the International Brass Symposium (Italy), Tainan National University (Taiwan), the National Orchestral Institute (University of Maryland), the New World Symphony, as well as the University of Michigan, Indiana University, Yale University and the Curtis Institute of Music, among many others.

A native of Storrs, Connecticut, Knox began formal musical studies on the classical guitar at age 6, and took up the baritone horn in the 5th grade. At age 11, while attending a summer music camp, he was so enamored of the student orchestra that he switched to tuba so he could pursue a life in music as an orchestral performer. His first teachers included Gary Ofenloch, Samuel Pilafian, and Chester Schmitz, and he attended the Curtis Institute of Music, where he studied with Paul Krzywicki of the Philadelphia Orchestra, and earned a Bachelor of Music degree.